Small-Molecule Control of Protein Degradation Using Split Adaptors
نویسندگان
چکیده
منابع مشابه
Small-molecule control of protein degradation using split adaptors.
Targeted intracellular degradation provides a method to study the biological function of proteins and has numerous applications in biotechnology. One promising approach uses adaptor proteins to target substrates with genetically encoded degradation tags for proteolysis. Here, we describe an engineered split-adaptor system, in which adaptor assembly and delivery of substrates to the ClpXP protea...
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ژورنال
عنوان ژورنال: ACS Chemical Biology
سال: 2011
ISSN: 1554-8929,1554-8937
DOI: 10.1021/cb2001389